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Patients with the following should not use Phentermine:

An allergy to any ingredient in Phentermine or other sympathomimetics (eg, pseudoephedrine)

Are also taking dexfenfluramine, fenfluramine, furazolidone, guanadrel, guanethidine, or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) in the last 14 days.

Have severe high blood pressure, an overactive thyroid, glaucoma, heart or blood vessel disease, or severe narrowing of the blood vessels

Are in an agitated state, or have a history of substance abuse

Some medical conditions may interact with Phentermine, patients with the following should consult with their doctor before using phentermine:

Are pregnant, planning to become pregnant, or are breast-feeding

Are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

Have allergies to medicines, foods, or other substances

Have a brain or spinal cord disorder, hardening of the arteries, high blood pressure, diabetes, or high cholesterol or lipid levels

Some medicines may interact with phentermine, such as the following:

Dexfenfluramine, fenfluramine, furazolidone, or MAOIs (eg, phenelzine) because the risk of serious side effects, such as increasing headache, high blood pressure, slow heart rate, elevated temperature, or possibly fatal lung problems, may be increased

Guanadrel (Hylorel) or guanethidine (Ismelin) because their effectiveness may be decreased by phentermine

Antacids: Antacids may decrease the excretion of phentermine.

Carbonic anhydrase inhibitors (acetazolamide, dichlorphenamide, methazolamide): Carbonic anhydrase inhibitors may decrease the excretion of phentermine.

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